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KMID : 0941820000100030125
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Korean Journal of Clinical Pharmacy
2000 Volume.10 No. 3 p.125 ~ p.129
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The Effect of Circadian Rhythm on the Gentamicin Pharmacokinetics in Rabbits
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Abstract
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The effect of circadian rhythm on gentamicin pharmacokinetics was studied in rabbits who took a single intravenous 2 mg/kg dose of gentamicin at 09:00 in the morning (a.m.) and 22:00 in the evening (p.m.). A significant circadian rhythm of pharmacokinetic parameters as a function of time of day was noted in rabbits, showing lower total body clearance CL_t and higher serum area under the curve (AUC) when given in the evening. The half-life t_{1/2} was shorter in the morning (3.88pm0.62h) when compared to the evening (4.76pm0.75;h). The AUC was greater in the evening (25.92pm3.49;{mu}g/ml{cdot}hr) than that in the morning (22.42pm3.42;{mu}g/ml{cdot}hr), most likely because the CLt was significantly higher when gentamicin was given in the morning (0.18pm0.28;ml/hr) versus in the evening (0.15pm0.26;ml/hr). The t_{1/2} of gentamicin in the evening was increased significantly(p<0.05) compared to those of gentamicin in the morning. It is reasonable to consider individual circadian rhythm for effective dosage regimen of gentamicin in clinical chronotherapeutics.
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